221198-22-7

Upstream product

• 28252-50-8 N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 221198-05-6 N-Boc-Thr[N-Fmoc-D-Ala]-OBn 
• 221198-17-0 N-Boc-Thr-{[N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn]-D-Ala}-{N-[(4S)-4-amino-6-methyl-3-oxo-2-(triphenylphosphoranylidene)heptanoyl]-Leu}-OBn 
• 221198-10-3 N-Boc-Thr[N-Fmoc-D-Ala]-{N-[(4S)-4-amino-6-methyl-3-oxo-2-(triphenylphosphoranylidene)heptanoyl]-Leu}-OBn 
• 221198-00-1 N-((S)-4-{[(tert-butoxy)carbonyl]amino}-6-methyl-3-oxo-2-(triphenylphosphoranylidene)heptanoyl)-Leu-OBn 
• 909115-21-5 N-Boc-Thr[N-Fmoc-D-Ala]-OH 
• 221197-86-0 N-(2-bromoacetyl)-L-leucine benzyl ester 
• 140422-54-4 N-(tert-butyloxycarbonyl)-threonine benzyl ester 
• 1738-69-8 L-Leucine benzyl ester 

Downstream Products

• 157951-38-7 YM-47141 
• 221198-49-8 N-[N(isopropylacetyl)-Phe-Thr]-Thr-{N-[(4S)-4-amino-6-methyl-3-oxo-2-(triphenylphosphoranylidene)heptanoyl]-Leu}-Asn-D-Ala (threonine hydroxy) lactone 
• 221198-28-3 N-[N(phenylacetyl)-Phe-Thr]-Thr-{N-[(4S)-4-amino-6-methyl-3-oxo-2-(triphenylphosphoranylidene)heptanoyl]-Leu}-Asn-D-Ala (threonine hydroxy) lactone 

Relevant academic research and scientific papers

The chemistry of vicinal tricarbonyls: Total syntheses of elastase inhibitors YM-47141 and YM-47142

We have completed the total syntheses of elastase inhibitors YM-47141 and YM-47142, the first natural products containing a vicinal tricarbonyl group. The work establishes the configuration at C(4) of the macrocyclic depsipeptide and demonstrates the gene