2212-07-9

Basic information

• Product Name: 2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE
• Synonyms: Oxirane,2-[(2,4-dichlorophenoxy)Methyl]-
• CAS NO: 2212-07-9
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06
• Mol File: 2212-07-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.5 °C at 760 mmHg
• Flash Point: 124.3 °C
• Appearance: /
• Density: 1.389 g/cm³
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE(2212-07-9)
• EPA Substance Registry System: 2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE(2212-07-9)

Safety Data

• Hazardous Substances Data: 2212-07-9(Hazardous Substances Data)

Usage

General Description

2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE, commonly known as 2,4-Dichlorophenoxyacetic acid (2,4-D), is a synthetic auxin herbicide used to control broadleaf weeds. It was first introduced in the 1940s and is one of the most widely used herbicides in the world. 2,4-D works by mimicking the action of the natural plant hormone auxin, causing uncontrolled growth and eventually killing the plant. It is primarily used in agricultural settings, but can also be found in residential lawn care products. Concerns have been raised about its potential health and environmental impacts, including links to cancer and reproductive issues, leading to restrictions on its use in some countries.

InChI:InChI=1/C9H8Cl2O2/c10-6-1-2-9(8(11)3-6)13-5-7-4-12-7/h1-3,7H,4-5H2/t7-/m1/s1

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 1370596-07-8 1-azido-3-(2,4-dichlorophenyl)propan-2-ol 
• 64319-22-8 3-(2',4'-dichlorophenoxy)-1-(n-heptylthio)-2-propanol 
• 5330-18-7 1-(2,4-dichloro-phenoxy)-propan-2-ol 
• 862300-55-8 (+/-)-1-(2,4-dichlorophenoxy)-3-thiocyanatopropan-2-yl acetate 
• 59630-50-1 GD-7 
• 2933-92-8 1-(2,4-Dichlor-phenoxy)-3-isopropylamino-propanol-⁽²⁾ 
• 21282-27-9 1-[butyl-(2-morpholin-4-yl-ethyl)-amino]-3-(2,4-dichloro-phenoxy)-propan-2-ol 

Relevant articles and documents

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents

The Gram-negative bacterium Acinetobacter baumannii is an opportunistic pathogen in humans and infections are poorly treated by current therapy. Recent emergence of multi-drug resistant strains and the lack of new antibiotics demand an immediate action for development of new anti-Acinetobacter agents. To this end, oxidative phosphorylation (OxPhos) was identified as a novel target for drug discovery research. Consequently, a library of ～10,000 compounds was screened using a membrane-based ATP synthesis assay. One hit identified was the 2-iminobenzimidazole 1 that inhibited the OxPhos of A. baumannii with a modestly high selectivity against mitochondrial OxPhos, and displayed an MIC of 25 μM (17 μg/mL) against the pathogen. The 2-iminobenzimidazole 1 was found to inhibit the type 1 NADH-quinone oxidoreductase (NDH-1) of A. baumannii OxPhos by a biochemical approach. Among various derivatives that were synthesized to date, des-hydroxy analog 5 is among the most active with a relatively tight SAR requirement for the N′-aminoalkyl side chain. Analog 5 also showed less cytotoxicity against NIH3T3 and HepG2 mammalian cell lines, demonstrating the potential for this series of compounds as anti-Acinetobacter agents. Additional SAR development and target validation is underway.

Regioselective ring-opening of epoxides by carbazole: A direct preparation of novel N-(β-hydroxyalkyl)carbazoles

The influence of various parameters including solvent, base and temperature on the reaction between carbazole and epoxides was studied This led to the development of a regioselective ring-opening of epoxides by the potassium salt of carbazole in DMSO at 100 °C which is a straightforward way to prepare new N-(β-hydroxyalkyl)carbazoles in good to excellent yields. Fifteen new compounds are described.

1-(benzylpiperidino)propan-2-ol derivatives, their preparation, their use as antimicrobial agents and the products in which they are present

The invention relates to compounds of the formula: STR1 in which: Ar represents a phenyl group substituted by R2, R3 and R4, or a naphth-1-yl or naphth-2-yl group, unsubstituted or substituted by 1 or 2 halogen atoms; X represents an oxygen atom or a sulfur atom; R1 represents H or a halogen atom; R2 represents a halogen atom, a trifluoromethyl group, a phenyl group which is unsubstituted by 1 or 3 halogen atoms, a benzyl group which is unsubstituted or substituted by 1 to 3 halogen atoms, a phenoxy group which is unsubstituted or substituted by 1 to 3 halogen atoms, or a C1 -C4 alkyl group; R3 and R4 represents H, a halogen atom or a C1 -C4 alkyl group; and the benzyl group substitutes the piperidino radical in the 2-, 3- or 4-position, and their salts with mineral or organic acids. It also relates to a process for the preparation of said compounds and their use as antimicrobial agents, as antiseptic, disinfectant, preservative in different kinds of products (pharmaceutical compositions, cosmetics, agri-foodstuffs). It also relates to said products containing the compounds of formula (I).