2212-07-9

Usage

Uses

Used in Agricultural Industry:
2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE is used as a herbicide for controlling broadleaf weeds in various agricultural settings. Its application helps protect crops from being overtaken by unwanted plants, ensuring a healthy and productive yield.
Used in Residential Lawn Care:
2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE is also used in residential lawn care products to maintain the aesthetic appeal of lawns and gardens by eliminating broadleaf weeds that can compete with desired grasses and plants.
However, it is important to note that concerns have been raised about the potential health and environmental impacts of 2-[(2,4-DICHLOROPHENOXY)METHYL]OXIRANE, including links to cancer and reproductive issues. As a result, some countries have imposed restrictions on its use.

InChI:InChI=1/C9H8Cl2O2/c10-6-1-2-9(8(11)3-6)13-5-7-4-12-7/h1-3,7H,4-5H2/t7-/m1/s1

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 106-89-8 epichlorohydrin 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 100793-03-1 1-(2,4-dichloro-phenoxy)-3-piperidino-propan-2-ol 
• 109129-49-9 1-(2,4-dichloro-phenoxy)-3-(2,3,5,6-tetrahydro-imidazo[1,2-a]imidazol-1-yl)-propan-2-ol 
• 21282-27-9 1-[butyl-(2-morpholin-4-yl-ethyl)-amino]-3-(2,4-dichloro-phenoxy)-propan-2-ol 
• 2933-92-8 1-(2,4-Dichlor-phenoxy)-3-isopropylamino-propanol-⁽²⁾ 
• 59630-50-1 GD-7 
• 862300-55-8 (+/-)-1-(2,4-dichlorophenoxy)-3-thiocyanatopropan-2-yl acetate 
• 5330-18-7 1-(2,4-dichloro-phenoxy)-propan-2-ol 
• 64319-22-8 3-(2',4'-dichlorophenoxy)-1-(n-heptylthio)-2-propanol 
• 1370596-07-8 1-azido-3-(2,4-dichlorophenyl)propan-2-ol 

Relevant academic research and scientific papers

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents

The Gram-negative bacterium Acinetobacter baumannii is an opportunistic pathogen in humans and infections are poorly treated by current therapy. Recent emergence of multi-drug resistant strains and the lack of new antibiotics demand an immediate action for development of new anti-Acinetobacter agents. To this end, oxidative phosphorylation (OxPhos) was identified as a novel target for drug discovery research. Consequently, a library of ～10,000 compounds was screened using a membrane-based ATP synthesis assay. One hit identified was the 2-iminobenzimidazole 1 that inhibited the OxPhos of A. baumannii with a modestly high selectivity against mitochondrial OxPhos, and displayed an MIC of 25 μM (17 μg/mL) against the pathogen. The 2-iminobenzimidazole 1 was found to inhibit the type 1 NADH-quinone oxidoreductase (NDH-1) of A. baumannii OxPhos by a biochemical approach. Among various derivatives that were synthesized to date, des-hydroxy analog 5 is among the most active with a relatively tight SAR requirement for the N′-aminoalkyl side chain. Analog 5 also showed less cytotoxicity against NIH3T3 and HepG2 mammalian cell lines, demonstrating the potential for this series of compounds as anti-Acinetobacter agents. Additional SAR development and target validation is underway.

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Regioselective ring-opening of epoxides by carbazole: A direct preparation of novel N-(β-hydroxyalkyl)carbazoles

The influence of various parameters including solvent, base and temperature on the reaction between carbazole and epoxides was studied This led to the development of a regioselective ring-opening of epoxides by the potassium salt of carbazole in DMSO at 100 °C which is a straightforward way to prepare new N-(β-hydroxyalkyl)carbazoles in good to excellent yields. Fifteen new compounds are described.

A novel method for synthesis of aryl glycidyl ethers

A solid-liquid phase-transfer catalytic method for the synthesis of aryl glycidyl ethers has been described, and the factors affecting the reaction yield have been examined.

1-(benzylpiperidino)propan-2-ol derivatives, their preparation, their use as antimicrobial agents and the products in which they are present

The invention relates to compounds of the formula: STR1 in which: Ar represents a phenyl group substituted by R2, R3 and R4, or a naphth-1-yl or naphth-2-yl group, unsubstituted or substituted by 1 or 2 halogen atoms; X represents an oxygen atom or a sulfur atom; R1 represents H or a halogen atom; R2 represents a halogen atom, a trifluoromethyl group, a phenyl group which is unsubstituted by 1 or 3 halogen atoms, a benzyl group which is unsubstituted or substituted by 1 to 3 halogen atoms, a phenoxy group which is unsubstituted or substituted by 1 to 3 halogen atoms, or a C1 -C4 alkyl group; R3 and R4 represents H, a halogen atom or a C1 -C4 alkyl group; and the benzyl group substitutes the piperidino radical in the 2-, 3- or 4-position, and their salts with mineral or organic acids. It also relates to a process for the preparation of said compounds and their use as antimicrobial agents, as antiseptic, disinfectant, preservative in different kinds of products (pharmaceutical compositions, cosmetics, agri-foodstuffs). It also relates to said products containing the compounds of formula (I).

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Novel compounds of the general formula STR1 and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form --OCH2 O--; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonylmethyl, cyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form --CH=CH--CH=CH--; R7 and R8 together form --OCH2 O--; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.

A NEW APPLICATION OF CORRELATION EQUATIONS. INFLUENCE OF SUBSTITUENT ON BASICITY OF A SERIES OF CHLOROPHENYL GLYCIDYL ETHERS

The relation between the basicity of simple oxiranes and substituent constants was described earlier by the common equation pKb=co+c1?.It has been shown that this equation is not satisfied in the case of chlorophenyl glycidyl ethers, when the pKa values of chlorophenols have been taken as a measure of the inductive effect of chlorophenoxy substituent and pKb have been estimated from infrared measurements.The modification of the equation to the following form: pKb=co+(c1+c2Sk)pKa by considerarion of the conformation factor Sk make a good correlation possible.The possibility of the existence of some chlorophenyl glycidyl ethers rotameres has been also discussed on the above basis.