22120-39-4

Basic information

• Product Name: 5-METHYL-N,N-DIMETHYLTRYPTAMINE
• Synonyms: N,N-DIMETHYL-METHYLTRYPTAMINE;5-METHYL-N,N-DIMETHYLTRYPTAMINE;3-(2-(dimethylamino)ethyl)-5-methyl-indol;3-(2-dimethylaminoethyl)-5-methylindole;n,n-dimethyl-5-methyltryptamine;N,N-DIMETHYL-METHYLTRYPTAMINE free base;3-[2-(Dimethylamino)ethyl]-5-methyl-1H-indole;N,N,5-Trimethyl-1H-indole-3-ethanamine
• CAS NO: 22120-39-4
• Molecular Formula: C13H18N2
• Molecular Weight: 202.3
• Product Categories: Tryptamines
• Mol File: 22120-39-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 330.43°C (rough estimate)
• Flash Point: 164.4°C
• Appearance: /
• Density: 0.9400 (rough estimate)
• Vapor Pressure: 5.11E-05mmHg at 25°C
• Refractive Index: 1.4400 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5-METHYL-N,N-DIMETHYLTRYPTAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-N,N-DIMETHYLTRYPTAMINE(22120-39-4)
• EPA Substance Registry System: 5-METHYL-N,N-DIMETHYLTRYPTAMINE(22120-39-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: NL7420000
• Hazardous Substances Data: 22120-39-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 22120-39-4 differently. You can refer to the following data:
1. 5-METHYL-N,N-DIMETHYLTRYPTAMINE is used in the synthesis of 3-fluorooxindole derivatives that have potential pharmaceutical application, such as in the production of antimigrane drugs.
2. N,N-5-Trimethyl-1H-indole-3-ethanamine is used in the synthesis of 3-fluorooxindole derivatives that have potential pharmaceutical application, such as in the production of antimigrane drugs.

InChI:InChI=1/C13H18N2/c1-10-4-5-13-12(8-10)11(9-14-13)6-7-15(2)3/h4-5,8-9,14H,6-7H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 1821-47-2 5-methyltryptamine 
• 77-78-1 dimethyl sulfate 
• 19718-92-4 4-(N,N-dimethylamino)butyraldehyde dimethyl acetal 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 74-88-4 methyl iodide 

Downstream Products

• 144034-80-0 rizatriptan 

Relevant articles and documents

Indole derivatives and its application on the medicament

The invention provides indole derivatives or stereisomers, tautomers, nitrogen oxides, solvate, metabolic products, pharmaceutically acceptable salts or prodrugs thereof for treating the alzheimer disease. The invention further discloses a pharmaceutical composition containing the compounds and a method of using the compounds or the pharmaceutical composition thereof to treat the alzheimer disease.

Synthesis and structureactivity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands

5-Hydroxytryptamine 6 receptors (5-HT6R) are being perceived as the possible target for treatment of cognitive disorders as well as obesity. The present article deals with the design, synthesis, in vitro binding and structureactivity relationship of a novel series of tetracyclic tryptamines with the rigidized N-arylsulphonyl, N-arylcarbonyl and N-benzyl substituents as 5-HT6 receptor ligands. The chiral sulphonyl derivatives 15a and 17a showed high affinity at 5-HT6R with the Ki of 23.4 and 20.5nM, respectively. The lead compound from the series 15a has acceptable ADME properties, adequate brain penetration and is active in animal models of cognition like Novel Object Recognition Task (NORT) and water maze.

Improved Fischer indole reaction for the preparation of N,N-dimethyltryptamines: Synthesis of L-695-894, a potent 5-HT(1D) receptor agonist

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