221218-33-3

Basic information

• Product Name: 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE)
• Synonyms: 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE)
• CAS NO: 221218-33-3
• Molecular Formula: C₈H₆FNO₂
• Molecular Weight: 167.1371432
• Mol File: 221218-33-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 238.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE)(221218-33-3)
• EPA Substance Registry System: 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE)(221218-33-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 221218-33-3(Hazardous Substances Data)

Usage

General Description

2-fluoro-4-isocyanato-1-methoxybenzene, also known as SALTDATA: FREE, is a chemical compound that consists of a benzene ring with a 2-fluoro and 1-methoxy substitution. It also contains an isocyanato functional group. 2-fluoro-4-isocyanato-1-methoxybenzene(SALTDATA: FREE) is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has a molecular weight of 171.14 g/mol and a boiling point of 212 degrees Celsius. It is important to handle this chemical with caution as it is toxic and irritant to the skin and eyes.

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 1354790-53-6 C₁₇H₁₅FN₄O₃ 
• 259227-23-1 N,N-dibenzyl-4-[3-(3-fluoro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide 
• 221219-10-9 (3-fluoro-4-methoxy-phenyl)-carbamic acid 2-(4-dibenzylsulfamoyl-phenyl)-2-oxo-ethyl ester 

Relevant articles and documents

Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates- and ureas-derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6-tetramethylpiperidin- 1-yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.

N - (4 - (3 - amino - 1 H - indazole - 4 - yl) phenyl) - N' - (2 - fluoro - 5 - methylphenyl) urea intermediate preparation method

The invention provides a preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and an intermediate thereof. Specifically, the invention provides a preparation method of a borate ester compound as shown in a formula I, and the preparation method comprises the following steps: enabling a compound as shown in a formula III to react with a compound as shown in a formula IV to generate a compound as shown in a formula V, and enabling the compound as shown in the formula V to react with a boron reagent to generate the compound as shown in the formula I. The method has the characteristics of convenience in reaction, easiness in obtainment of the intermediate, high yield, high product purity of above 98.5%, low cost of raw materials and the like, and is suitable for industrial application.