221221-12-1

Basic information

• Product Name: ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate
• Synonyms: ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate
• CAS NO: 221221-12-1
• Molecular Formula: C₁₂H₁₂F₂O₄
• Molecular Weight: 258.2180864
• Mol File: 221221-12-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.251±0.06 g/cm3(Predicted)
• PKA: 10.43±0.50(Predicted)
• CAS DataBase Reference: ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate(221221-12-1)
• EPA Substance Registry System: ethyl 3-(2,4-difluoro-3-methoxyphenyl)-3-oxopropanoate(221221-12-1)

Safety Data

• Hazardous Substances Data: 221221-12-1(Hazardous Substances Data)

Upstream product

• 373603-19-1 2,4-difluoro-3-methoxyacetophenone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 221221-13-2 ethyl 2-(2,4-difluoro-3-methoxybenzoyl)-3-cyclopropylaminoacrylate 
• 221221-15-4 ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate 

Relevant articles and documents

ANTIBACTERIAL FLUOROQUINOLONE ANALOGS

Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Coupling process for preparing quinolone intermediates

Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process.

PROCESS FOR PREPARING QUINOLONE ANTIBIOTIC INTERMEDIATES

The present invention relates to a process for preparing a quinolone antibiotic intermediate having the formula: wherein R is C1-C2 alkyl, C1-C2 fluoroalkyl, C2-C4 alkenyl, methoxy, chloro, or bromo; R1 is a unit selected from the group consisting of C1-C