221246-11-3Relevant academic research and scientific papers
Suzuki reaction of a diarylborinic acid: One-pot preparation and cross-coupling of bis(3,5-dimethylphenyl)borinic acid
Winkle, Derick D.,Schaab, Kevin M.
, p. 450 - 451 (2013/09/07)
3,5-Dimethylphenylmagnesium bromide reacts with triisopropyl borate to give 3,5-dimethylphenylboronic acid and bis(3,5-dimethylphenyl)borinic acid. Conditions were found which allowed the clean preparation of bis(3,5-dimethylphenyl)borinic acid, which was coupled with a vinyl triflate using Suzuki cross-coupling conditions. Both aryl groups were efficiently transferred from boron in the Suzuki step.
Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
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, (2008/06/13)
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
