221272-64-6

Upstream product

• 104410-90-4 tert-butyldimethylsilyl trifluoroacetate 
• 203200-33-3 1-[3-O-(vinyldimethylsilyl)-2-deoxy-5-O-(dimethoxytrityl)-4-C-(phenylseleno)-α-L-threo-pento-1,4-furanosyl]thymine 
• 203200-32-2 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-5-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 203200-35-5 5'-O-(dimethoxytrityl)-4'-C-(2-hydroxyethyl)thymidine 

Downstream Products

• 267243-98-1 4'α-C-(2-azidoethyl)-3'-O-(tert-butyldimethylsilyl)-5'-O-(dimethoxytrityl)thymidine 
• 267244-00-8 4'-C-(2-azidoethyl)-5'-O-(dimethoxytrityl)thymidine 
• 267244-04-2 5'-O-(dimethoxytrityl)-4'-C-[2-(N-trifluoroacetyl)aminoethyl]thymidine 
• 221272-65-7 1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(2-phenylselanyl-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 591754-20-0 5'-O-(4,4'-dimethoxysilyl)-4'-C-(ethyl)thymidine 
• 246022-21-9 5'-O-(4,4'-dimethoxytrityl)-4'αC-vinylthymidine 

Relevant academic research and scientific papers

Highly nuclease-resistant phosphodiester-type oligodeoxynucleotides containing 4′α-C-aminoalkylthymidines form thermally stable duplexes with DNA and RNA. A candidate for potent antisense molecules

The properties of phosphodiester oligodeoxynucleotides (ODNs) containing 4′α-C-aminomethyl, -ethyl, -propyl, and -N-(2-aminoethyl)carbamoylthymidines (1, 2, 4, and 5) as potential antisense molecules are investigated in detail. We developed new radical ch

Nucleosides and nucleotides. 183. Synthesis of 4'α-branched thymidines as a new type of antiviral agent

A series of 4'αr-branched thymidines was synthesized and evaluated as potential antiviral agents. 4'-Ethylthymidine (3), 4'-ethenylthymidine (5), and 4'-ethynylthymidine (6) exhibited potent anti-HSV-1 and anti-HIV-1 activities with no significant cytotoxicity.