221279-43-2Relevant academic research and scientific papers
Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide
Gupta,Wagh
, p. 697 - 702 (2007/10/03)
A series of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride (MA) followed by cyclization with o-aminothiophenol (o-ATP). All the compounds have been screened for their antifungal activity against Tricophyton rubrum, Epidermophyton floccosum and Malassazia furfur. In the primary screening, some of the compounds exhibited appreciable activity. The structures of the synthesized compounds 7a-z have been established on the basis of elemental analysis and spectral data.
Addition of secondary amines to maleamic esters and maleimides
Bergman, Jan,Brimert, Thomas
, p. 48 - 56 (2007/10/03)
Contrary to some literature claims, secondary amines such as piperidine or their acetates do not promote the cyclization of maleanilic esters with activated orthoalkyl groups to form 2-quinolones, but instead they add to the maleic double bond, to produce 3-aminosuccinimides or 3-aminosuccinamic esters, depending on the conditions used. This and similar reactions were studied and also an alternative synthesis of 7-nitro-3-(2-oxo-2-piperidin-1-ylethyl)-3,4-dihydroquinolin-2(1H)-one was achieved utilizing the Schmidt reaction as the key step. Copyright Acta Chemica Scandinavica 1999.
