221289-88-9

Basic information

• Product Name: 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
• Synonyms: 1H-Benzimidazole-5-carbonitrile,2,3-dihydro-2-oxo-(9CI);2-oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile(SALTDATA: FREE);1H-BenziMidazole-5-carbonitrile, 2,3-dihydro-2-oxo-;2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile;2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
• CAS NO: 221289-88-9
• Molecular Formula: C8H5N3O
• Molecular Weight: 159.14
• Product Categories: BENZIMIDAZOLE
• Mol File: 221289-88-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 189.3±19.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.98±0.30(Predicted)
• CAS DataBase Reference: 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE(221289-88-9)
• EPA Substance Registry System: 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE(221289-88-9)

Safety Data

• Hazardous Substances Data: 221289-88-9(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-2-oxo-1H-benzimidazole-5-carbonitrile is a chemical compound with the molecular formula C9H6N4O. It is a benzimidazole derivative that has potential applications in pharmaceutical research and development, due to its ability to interact with biological systems. 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE is known for its diverse range of pharmacological activities, including antiviral, antitumor, and anti-inflammatory properties. Additionally, it has been studied for its potential use in the treatment of various diseases, making it an important target for further investigation and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 6393-40-4 4-Amino 3-nitro-benzonitrile 
• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 57-13-6 urea 

Downstream Products

• 401567-00-8 2-chlorobenzimidazole-5-carbonitrile 
• 106429-59-8 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbaldehyde 

Relevant articles and documents

Selenium-Catalyzed Carbonylative Synthesis of 2-Benzimidazolones from 2-Nitroanilines with TFBen as the CO Source

A selenium-catalyzed carbonylative reaction for the synthesis of 2-benzimidazolones from 2-nitroanilines has been developed. In this strategy, to avoid the usage of toxic CO gas, TFBen (benzene-1,3,5-triyl triformate) was used as a solid and stable CO precursor, and a variety of desired 2-benzimidazolones were produced in moderate to excellent yields.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

METALLOENZYME INHIBITOR COMPOUNDS

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.