2213-71-0

Upstream product

• 95-95-4 2,4,5-trichlorophenol 
• 6138-29-0 C₆H₂Cl₃O^(1-)*5H₂O*Na⁽¹⁺⁾ 

Downstream Products

• 20194-77-8 phosphoric acid mono-(2,4,5-trichloro-phenyl ester) 
• 3983-45-7 ronnel oxon 
• 20362-80-5 chlorpyrifos oxon 
• 38578-27-7 5,5-Bis-bromomethyl-2-(2,4,5-trichloro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide 
• 115142-21-7 Phosphoric acid (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl ester 2,4,5-trichloro-phenyl ester 
• 115142-07-9 Phosphoric acid (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester 2,4,5-trichloro-phenyl ester 

Relevant academic research and scientific papers

Charge Description of Base-Catalyzed Alcoholysis of Aryl Phosphodiesters: A Ribonuclease Model

The release of substituted phenol from aryl uridine-3'-phosphates is catalyzed by bases and involves cyclization to form the 2',3'-cyclic nucleotide.The rate constants for imidazole and hydroxide ion catalysis (kim and kOH, respectively) obey the Broensted equations (25 deg C and 0.25 M ionic strength) log kim = -0.59 pKArOH + 1.40 (n = 7, r = 0.955) and log kOH = -0.54 pKArOH + 6.68 (n = 9, r = 0.967).General-base-catalyzed release of 4-nitrophenol from the 4-nitrophenyl ester (kB) obeys the Broensted relationship log kB = 0.67 pKBH - 7.50 (n = 7, r = 0.989).Charge changes on base and leaving group atoms as determined from the corresponding β and βeq values do not balance.Comparison with data in the literature indicates that the difference in charge may be assigned to the attacking oxygen (2'-hydroxyl) rather than to the phosphoryl oxygens in the O...PO2... group of atoms.Both P-O bond forming and bond fission components of the reaction are considered to be only weakly advanced in a transition state that lies on a concerted pathway.