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22131-35-7

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22131-35-7 Usage

Description

Butalamine is a vasodilator with peripheral action and local anesthetic properties. It has been demonstrated to inhibit state 3 respiration and decrease ADP/O in rat liver, indicating its potential effects on cellular metabolism and energy production.

Uses

Used in Pharmaceutical Industry:
Butalamine is used as a vasodilator for its ability to improve blood flow and reduce peripheral vascular resistance. This can be beneficial in treating conditions where increased blood flow is necessary, such as in cases of hypertension or other circulatory issues.
Additionally, butalamine is used as a local anesthetic due to its numbing effect on tissues. This makes it a valuable compound for use in medical procedures where local pain relief is required, such as in minor surgeries or dental work.
Used in Research Applications:
In the field of scientific research, butalamine is used as a tool to study the effects of vasodilation and local anesthesia on cellular respiration and energy metabolism. Its ability to inhibit state 3 respiration and decrease ADP/O in rat liver provides valuable insights into the mechanisms underlying these processes and can contribute to the development of new therapeutic strategies for various medical conditions.

Originator

Surheme,Aron,France,1969

Manufacturing Process

Benzaldehyde and hydroxylamine may be reacted, the product chlorinated and then reacted with cyanamide to give 5-amino-3-phenyl-1,2,4-oxadiazole. 32 grams of 3-phenyl-5-amino-1,2,4-oxadiazole dissolved in about 150 ml of anhydrous benzene, 7.8 grams of sodium amide are added and the reaction mixture heated at the boiling point with stirring for 2 hours. A solution of 38.3 grams of dibutylaminoethyl chloride in benzene is then added and the mixture heated to boiling under reflux for four hours. The sodium chloride is separated as previously described, the benzene removed by vacuum distillation and 56 grams of 3-phenyl-5-(dibutylaminoethylamino)-1,2,4-oxadiazole is obtained in the form of an oil which is then converted directly to the crystalline hydrochloride. This is accomplished by dissolving the oil in ethanol and adding the stoichiometric equivalent of anhydrous ethyl ether saturated with gaseous hydrogen chloride. The recrystallized salt is found to have a melting point of 145°C.

Therapeutic Function

Vasodilator

Check Digit Verification of cas no

The CAS Registry Mumber 22131-35-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,1,3 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 22131-35:
(7*2)+(6*2)+(5*1)+(4*3)+(3*1)+(2*3)+(1*5)=57
57 % 10 = 7
So 22131-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H28N4O/c1-3-5-13-22(14-6-4-2)15-12-19-18-20-17(21-23-18)16-10-8-7-9-11-16/h7-11H,3-6,12-15H2,1-2H3,(H,19,20,21)

22131-35-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N',N'-dibutyl-N-(3-phenyl-1,2,4-oxadiazol-5-yl)ethane-1,2-diamine

1.2 Other means of identification

Product number -
Other names dibutylimolamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22131-35-7 SDS

22131-35-7Upstream product

22131-35-7Downstream Products

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