22131-84-6Relevant academic research and scientific papers
Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents
Matos, Maria J.,Vazquez-Rodriguez, Saleta,Santana, Lourdes,Uriarte, Eugenio,Fuentes-Edfuf, Cristina,Santos, Ysabel,Munoz-Crego, Angeles
, p. 1394 - 1404 (2013/04/23)
A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reported.
Fluorescent labeling of specific protein targets in vitro and in vivo
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, (2008/06/13)
New methods are provided for the post-genomic era that will permit the analysis of the dynamic expression and localization of gene products in living cells. Herein we propose the development of such a method from a bioorganic approach involving organic sy
Synthesis and characterization of dimaleimide fluorogens designed for specific labeling of proteins
Girouard, Stephane,Houle, Marie-Helene,Grandbois, Alain,Keillor, Jeffrey W.,Michnick, Stephen W.
, p. 559 - 566 (2007/10/03)
A series of aromatic compounds were prepared bearing two maleimide groups attached directly to the fluorescent cores. The resulting derivatives do not fluoresce until the maleimide groups undergo their typical thiol addition reaction, thus removing their
