221312-09-0Relevant articles and documents
Direct observation of binding between biotinylated okadaic acids and protein phosphatase 2A monitored by surface plasmon resonance
Konoki, Keiichi,Sugiyama, Naoyuki,Murata, Michio,Tachibana, Kazuo
, p. 887 - 890 (2007/10/03)
Two biotin conjugates of okadaic acid were synthesized for evaluating their interactions with protein phosphatase 2A by surface plasmon resonance (SPR). C7-biotinylated okadaic acid revealed strong binding affinity to the enzyme, while C1-biotinylated derivative being devoid of affinity, implying that the C7-biotin conjugate is a useful tool for biochemical studies of protein phosphatase 2A.