221312-74-9Relevant academic research and scientific papers
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity
Colucci, Marie A.,Reigan, Philip,Siegel, David,Chilloux, Aurélie,Ross, David,Moody, Christopher J.
, p. 5780 - 5789 (2007)
NAD(P)H:quinone oxidoreductase 1 is a proposed target in pancreatic cancer. We describe the synthesis of a series of indolequinones, based on the 5- and 6-methoxy-1,2-dimethylindole-4,7-dione chromophores with a range of phenolic leaving groups at the (in
Substituted benzene and heterocyclic compound and its preparation method and application
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Paragraph 0225; 0226; 0227; 0240; 0241; 0242, (2016/10/20)
The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.
Indolecarboxylic compounds and their use as pharmaceutical compounds
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, (2008/06/13)
The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat di
