221343-87-9Relevant academic research and scientific papers
Bis-Lewis acids-catalyzed highly diastereoselective one-pot reductive dehydroxylation of chiral N,O-acetals
Jiang, Li-Jiao,Teng, Bo,Zheng, Jian-Feng,Ye, Jian-Liang,Huang, Pei-Qiang
experimental part, p. 172 - 175 (2010/03/03)
A one-pot and highly diastereoselective method for the reductive dehydroxylation of three classes of heterocyclic N,O-acetals with general structure 4 is reported. The method features a 'two in one' concept, namely, by synergetic action of two complementary Lewis acids (BF·OEt2 and TiCl4), the bicyclic or tricyclic oxazololactams 5 were formed in situ and reductively cleaved to give the corresponding lactams 6 in a high-yielding and highly diastereoselective manner.
Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives
Allin, Steven M.,Northfield, Christopher J.,Page, Michael I.,Slawin, Alexandra M.Z.
, p. 1715 - 1721 (2007/10/03)
New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylglycinol
A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives
Allin, Steven M.,Northfield, Christopher J.,Page, Michael I.,Slawin, Alexandra M. Z.
, p. 143 - 146 (2007/10/03)
A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as h
