221349-77-5Relevant academic research and scientific papers
THROMBIN INHIBITORS
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Page column 18, (2010/01/30)
Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: or a pharmaceutically acceptable salt thereof, whereinA is whereinY 1 and Y 2 are independentlyhydrogen,C 1-4 alkyl,C 1-4 alkoxy,F uH v C(CH 2) 0-1 O--, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1,C 3-7 cycloalkyl,thio C 1-4 alkyl,C 1-4 sulfinylalkyl,C 1-4 sulfonylalkyl, halogencyano, ortrifluoromethyl, andwherein b is 0 or 1.
Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors
Coburn, Craig A.,Rush, Diane M.,Williams, Peter D.,Homnick, Carl,Lyle, Elizabeth A.,Lewis, S. Dale,Lucas Jr., Bobby J.,Di Muzio-Mower, Jillian M.,Juliano, Marylou,Krueger, Julie A.,Vastag, Kari,Chen, I-Wu,Vacca, Joseph P.
, p. 1069 - 1072 (2007/10/03)
A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
