221352-82-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidineaceticacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-(9CI) is used as a building block for the synthesis of various drugs and biologically active molecules. Its unique structure and reactivity allow for the preparation of diverse molecules, making it a valuable compound in the development of new pharmaceuticals.
Used in Drug Synthesis:
1-Piperidineaceticacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-(9CI) is used as a versatile intermediate in the synthesis of a wide range of pharmaceutical compounds. Its unique structure enables the creation of various drug candidates with potential therapeutic applications.
Used in Research and Development:
1-Piperidineaceticacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-(9CI) is used as a key component in research and development efforts aimed at discovering and developing new drugs and biologically active molecules. Its unique properties make it a promising candidate for further exploration and application in the pharmaceutical field.
Used in Therapeutic Applications:
1-Piperidineaceticacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-(9CI) has been studied for its potential therapeutic applications in the treatment of various medical conditions. Its unique structure and reactivity make it a promising candidate for the development of new treatments and therapies.

Upstream product

• 221352-86-9 (9H-fluoren-9-yl)methyl N-(piperidin-4-yl)carbamate monohydrochloride 
• 79-08-3 bromoacetic acid 

Relevant academic research and scientific papers

Improving the stability of peptidic radiotracers by the introduction of artificial scaffolds: Which structure element is most useful?

Peptidic radiotracers are highly potent substances for the specific in vivo imaging of various biological targets with Single Photon Emission Computed Tomography and Positron Emission Tomography. However, some radiolabeled peptides such as bombesin analogs were shown to exhibit only a limited stability, hampering a successful target visualization. One option to positively influence the stability of radiolabeled peptides is the introduction of certain artificial molecular scaffolds. In order to comparatively assess the influence of different structure elements on the stability of radiolabeled peptides and to identify those structure elements being most useful for peptide radiotracer stabilization, several monomeric and dimeric bombesin derivatives were synthesized, exhibiting differing molecular designs and the chelator NODAGA for 68Ga-labeling. The radiolabeled peptides were evaluated regarding their in vitro stability in human serum to determine the influence of the introduced molecular scaffolds on the peptides' serum stabilities. The results of the evaluations showed that the introduction of scaffold structures and the overall molecular design have a substantial impact on the stabilities of the resulting peptidic radiotracers. But besides some general trends found using certain scaffold structures, the obtained results point to the necessity to empirically assess their influence on stability for each susceptible peptidic radiotracer individually. In this contribution, the influence of different structure elements on the stability of 68Ga-labeled BBN(7-14) analogs was comparatively assessed by an in vitro serum stability assay with the aim to identify those structure elements being most useful for peptide radiotracer stabilization. It was found that the introduction of artificial scaffolds and the overall molecular design substantially affect the stabilities of the resulting peptidic radiotracers.