221353-39-5

Basic information

• Product Name: Ethyl 4-bromo-(2-phenylethynyl)phenylcarbamate
• Synonyms: Ethyl 4-bromo-(2-phenylethynyl)phenylcarbamate
• CAS NO: 221353-39-5
• Molecular Weight: 344.208
• Mol File: 221353-39-5.mol

Chemical Properties

• CAS DataBase Reference: Ethyl 4-bromo-(2-phenylethynyl)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-bromo-(2-phenylethynyl)phenylcarbamate(221353-39-5)
• EPA Substance Registry System: Ethyl 4-bromo-(2-phenylethynyl)phenylcarbamate(221353-39-5)

Safety Data

• Hazardous Substances Data: 221353-39-5(Hazardous Substances Data)

Upstream product

• 112671-47-3 ethyl (4-bromo-2-iodophenyl)carbamate 
• 536-74-3 phenylacetylene 

Downstream Products

• 83515-06-4 5-bromo-2-phenylindole 

Relevant articles and documents

Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.