221378-41-2

Upstream product

• 99-32-1 chelidonic acid 
• 221378-32-1 (2S,4S,6R)-4-Methoxymethoxy-tetrahydro-pyran-2,6-dicarboxylic acid diethyl ester 
• 221378-34-3 Acetic acid (2S,4S,6R)-6-acetoxymethyl-4-methoxymethoxy-tetrahydro-pyran-2-ylmethyl ester 
• 221378-36-5 Acetic acid (2R,4S,6S)-6-hydroxymethyl-4-methoxymethoxy-tetrahydro-pyran-2-ylmethyl ester 
• 221378-33-2 ((2S,4S,6R)-6-Hydroxymethyl-4-methoxymethoxy-tetrahydro-pyran-2-yl)-methanol 
• 725-92-8 diethyl 4-oxo-4H-pyran-2,6-dicarboxylate 
• 221378-40-1 Acetic acid (2R,4R,6S)-4-methoxymethoxy-6-triphenylsilanyloxymethyl-tetrahydro-pyran-2-ylmethyl ester 

Downstream Products

• 221378-42-3 Acetic acid (2R,4R,6S)-4-benzyloxy-6-triphenylsilanyloxymethyl-tetrahydro-pyran-2-ylmethyl ester 

Relevant academic research and scientific papers

Enzymatic desymmetrization of meso cis,cis-2,4,6-substituted tetrahydropyrans

The stereoselective acylation of meso-tetrahydropyrans 6 and 7 by enol esters (vinyl acetate or isopropenyl acetate) in the presence of Candida antarctica lipase in organic media gave the corresponding (2R,4S,6S)- monoesters 10 and 11 in high enantiomeric purity. The hydrolysis of the corresponding diacetate derivatives 8 and 9 in the presence of the same enzyme provided the opposite enantiomers, (2S,4R,6R)-monoesters 10 and 11.