221382-45-2

Upstream product

• 96-22-0 pentan-3-one 
• 221382-44-1 N-(2-amino-4-methoxycarbonylphenyl)-5-(2-hydroxyethyl)-5-(hydroxymethyl)pyrrolidin-2-one 
• 619-45-4 4-methoxycarbonyl aniline 
• 221382-03-2 diethyl 2-[4-(methoxycarbonyl)phenylamino]malonate 
• 221382-40-7 2-[4-(methoxycarbonylphenyl)amino]-γ-butyrolactone 
• 221382-41-8 spiro 2-(γ-butyrolactone)-5-[N-(4-methoxycarbonylphenyl)pyrrolidin-2-one] 
• 221382-42-9 spiro 2-(γ-butyrolactone)-5-[N-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one] 
• 221382-43-0 5-(2-hydroxyethyl)-5-hydroxymethyl-N-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one 
• 221382-38-3 diethyl 2-(2-acetoxyethyl)-2-[4-(methoxycarbonyl)phenylamino]malonate 

Relevant academic research and scientific papers

Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors

A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.

Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: Modifications of essential pyrrolidinone ring substituents

We recently reported the first benzoic acid, 1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one (8), that is a potent inhibitor of avian influenza A neuraminidase (N9) and, unlike other reported potent neuraminidase inhibitors, d