22140-20-1Relevant academic research and scientific papers
NOVEL ANTITHROMBOTIC DIADENOSINE TETRAPHOSPHATES AND RELATED ANALOGS
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Page/Page column 17-19, (2010/07/10)
The invention features compounds of formula I and methods of their use as antiplatelet and antithrombotic compounds: H /N=Qχ2 O O O O Λ Q2 — N, H R6/ N I f ) ( ^ XM O-Mγτ OM°τ X1MQ' ) r ( ^rf HO OH HO OQHi Nχi R2 Formula (I).
Identification of hydrolytically stable and selective P2Y1 receptor agonists
Eliahu, Shay E.,Camden, Jean,Lecka, Joanna,Weisman, Gary A.,Sevigny, Jean,Gelinas, Sylvie,Fischer, Bilha
experimental part, p. 1525 - 1536 (2009/08/15)
P2Y nucleotide receptors (P2YRs) are attractive pharmaceutical targets. Most P2YR agonists proposed as drugs consist of a nucleotide scaffold, but their use is limited due to their chemical and enzymatic instabilities. To identify drug candidates, we deve
Adenine nucleotide analogues locked in a Northern methanocarba conformation: Enhanced stability and potency as P2Y1 receptor agonists
Ravi, R. Gnana,Kim, Hak Sung,Servos, J?rg,Zimmermann, Herbert,Lee, Kyeong,Maddileti, Savitri,Boyer, José L.,Harden, T. Kendall,Jacobson, Kenneth A.
, p. 2090 - 2100 (2007/10/03)
Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a
The preparation of 32P-labeled 2-methylthioadenosine di- and triphosphates
Skoblov,Yas'ko,Skoblov
, p. 623 - 627 (2007/10/03)
2-Methylthioadenosine 5′-mono- and diphosphates were prepared by chemical synthesis, and enzymatically phosphorylated to 5′-[β-32P]-diphosphate and 5′-[γ-32P]-triphosphate, respectively. They were isolated by HPLC and had activity exceeding 1000 Ci/mmol and radiochemical purity higher than 95%.
