2215-63-6

Basic information

• Product Name: 1-Benzyl-3-hydroxy-1H-indazole
• Synonyms: 1-benzyl-2H-indazol-3-one;1-BENZYL-3-HYDROXY-1H-INDAZOLE;1-BENZYL-3-HYDROXYINDAZOLE;1-BENZYL-1H-INDAZOL-3-OL;1-BENZYL-2,3-DIHYDROINDAZOL-3-ONE;1-benzyl-1,2-dihydro-3h-indazol-3-one;BENZYL-3-HYDROXY-1H-INDAZOLE;1-BENZYL-3-HYDROXY-1H-INDAZOLE (BULK)
• CAS NO: 2215-63-6
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• EINECS: 218-680-4
• Product Categories: Indoles and derivatives;Aromatics;Intermediates;Indazoles
• Mol File: 2215-63-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 164-166 °C
• Boiling Point: 432.3 °C at 760 mmHg
• Flash Point: 215.3 °C
• Appearance: Beige powder
• Density: 1.243 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.86±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-hydroxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-hydroxy-1H-indazole(2215-63-6)
• EPA Substance Registry System: 1-Benzyl-3-hydroxy-1H-indazole(2215-63-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2215-63-6(Hazardous Substances Data)

Usage

Chemical Properties

Beige powder

InChI:InChI=1/C14H12N2O.Na/c17-14-12-8-4-5-9-13(12)16(15-14)10-11-6-2-1-3-7-11;/h1-9H,10H2,(H,15,17);/q;+1/p-1

Upstream product

• 1215-52-7 N-benzoyl-N'-benzylhydrazine 
• 7364-25-2 1H-indazol-3-ol 
• 100-44-7 benzyl chloride 
• 118-92-3 anthranilic acid 
• 7364-25-2 3-indazolinone 
• 100-39-0 benzyl bromide 
• 642-72-8 benzydamine 
• 1217-89-6 1-benzylisatin 
• 1067645-63-9 C₁₄H₁₃IN₂O 
• 614-31-3 N-benzyl-N-phenylhydrazine 
• 57-13-6 urea 
• 861578-52-1 1,5-dibenzyl-1,5-diphenyl carbonohydrazide 
• 872264-61-4 1-benzyl-1-phenyl semicarbazide 
• 34241-55-9 benzyl-phenyl-carbamoyl azide 

Downstream Products

• 602280-12-6 methyl 5-[(1-benzyl-1H-indazol-3-yl)oxy]-2-furoate 
• 1227057-56-8 C₂₁H₂₂N₂O₅ 
• 1300727-47-2 1-benzyl-3-difluoromethoxy-1H-indazole 
• 1300727-48-3 1-benzyl-2-difluoromethyl-1,2-dihydro-3H-indazol-3-one 
• 1300727-51-8 1-benzyl-3-bromodifluoromethoxy-1H-indazole 
• 1300727-53-0 1-benzyl-2-bromodifluoromethyl-3H-indazol-3-one 
• 1300727-52-9 1-benzyl-2-[(1-benzyl-1H-indazol-3-yloxy)difluoromethyl]-1,2-dihydroindazol-3-one 
• 1300727-55-2 1-benzyl-3-(1-fluorovinyloxy)-1H-indazole 
• 1300727-56-3 1-benzyl-3-(1,1-difluoroethoxy)-1H-indazole 
• 1300727-50-7 1-benzyl-3-(2,2-dichloro-1,1,2-trifluoroethoxy)-1H-indazole 
• 1300727-49-4 1-benzyl-3-(2-bromo-1,1,2,2-tetrafluoroethoxy)-1H-indazole 
• 1300727-57-4 1-benzyl-3-(1,2-difluoro-2-chlorovinyloxy)-1H-indazole 
• 13185-09-6 1-benzyl-3-indazolol sodium salt 
• 602279-88-9 2-[(1-benzyl-1H-indazol-3-yl)oxy]nicotinamide 

Relevant articles and documents

Metabolism of benzydamine hydrochloride.

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Synthesis of Indazolones via Friedel-Crafts Cyclization of Blocked (Masked) N-Isocyanates

Nitrogen-substituted isocyanates (N-isocyanates) are rare amphoteric reagents with high, but underdeveloped synthetic potential. Herein, we study the formation of indazolones by Friedel-Crafts cyclization of N-isocyanates using blocked (masked) N-isocyanate precursors: the effect of the masking group and the reaction scope have been delineated. Substrate synthesis has also been improved using a reported copper-catalyzed coupling of arylbismuth(V) reagents that is compatible with the hemilabile OPh blocking group.

Polyfluoroalkylation and alkenylation of 1-benzyl-1H-indazol-3-ol

The polyfluoroalkylation and alkenylation of 1-benzyl-1H-indazol-3-ol by halopolyfluoroalkanes and fluorinated olefins has been studied. It was shown that only reactions proceeding with the participation of difluorocarbene lead to a mixture of N- and O-alkylation products. In all other cases, interaction with halopolyfluoroethanes and polyfluoroalkenes forms O-polyfluoroalkyl and alkenyl derivatives of indazolol.