221526-05-2

Upstream product

• 221526-01-8 (S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid 
• 221525-71-9 (S)-6-Benzyloxycarbonylamino-2-[((2R,3R)-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid methyl ester 
• 221525-67-3 (2R,3R)-2-((S)-5-Benzyloxycarbonylamino-1-methoxycarbonyl-pentylcarbamoyl)-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 462124-94-3 (2S,3S)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 221525-87-7 (S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester 
• 221525-79-7 (S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionic acid 
• 118758-49-9 (2S,3S)-3-phenyl-pyrrolidine-2-carboxylic acid 
• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 

Relevant academic research and scientific papers

A convenient synthetic route to macrocyclic cis-3-phenylproline derivatives as mimics of Sandostatin

Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a- d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.