221539-67-9Relevant academic research and scientific papers
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Blundell, Tom L.,Botros, Sanaa S.,Campillo, Nuria E.,El-Lakkany, Naglaa M.,García-Rubia, Alfonso,Gil, Carmen,Maes, Louis,Martinez, Ana,Sabra, Abdel-Nasser A.,Sebastian-Perez, Victor,Seif el-Din, Sayed H.,William, Samia
, p. 511 - 523 (2020/01/23)
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in v
Synthesis, biological screening, and molecular docking of quinazolinone and quinazolinethione as phosphodiesterase 7 inhibitors
Elfeky, Sherin M.,Sobahi, Tariq R.,Gineinah, Magdy M.,Ahmed, Nesreen S.
, (2019/11/16)
N-Substituted isatoic anhydrides were used as starting materials for the synthesis of compounds 5–16 through alkali hydrolysis, Schiff base reactions, and oxidation. Compounds 18–23 were obtained by thionation of their oxo isosteres using Lawesson's reage
Ultrasound one pot synthesis of fused quinazolinones and quinazolinediones, screening and molecular docking study as phosphodiesterase 7A inhibitors
Elfeky, Sherin M.,Sobahi, Tariq R.,Gineinah, Magdy M.,Ahmed, Nesreen S.
, p. 1451 - 1466 (2019/09/18)
Ppotent HOSPHODIESTERASE anti-inflammatory 7A agents enzyme with is minimal one of side the effects. most recent Quinazolinones targets for are designing un
