22156-47-4

Upstream product

• 77446-17-4 1-allyl-3,5-dimethylbenzene 
• 5779-95-3 3,5-dimethylbenzaldehyde 
• 36440-57-0 methyl 4-(3,5-dimethylphenyl)-4-oxobutanoate 
• 556-96-7 5-bromo-1,3-xylene 
• 313058-69-4 2-[3-(3,5-dimethyl-phenyl)-propyl]-[1,3]dioxolane 
• 36440-58-1 4-(3,5-dimethylphenyl)-4-oxobutanoic acid 

Downstream Products

• 17057-91-9 2,4,5-trimethylnaphthalene 
• 13621-25-5 5,7-dimethyltetralone 

Relevant academic research and scientific papers

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Integrated chemical process: One-pot aromatization of cyclic enones by the double elimination methodology

A variety of aromatic hydrocarbons bearing multiple alkyl substituents are accessible with perfect regiocontrol in a one-pot reaction starting from cyclo-hexenones and their aromatic analogues [Eq. (1)]. The present methodology can be further extended to the synthesis of polycyclic aromatic hydrocarbons. The drawbacks encountered in the Friedel-Crafts reaction are resolved since the reaction proceeds under basic conditions.