221619-50-7

Basic information

• Product Name: 5-(1,3-diphenyl-1H-pyrazol-4-yl)-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one
• Synonyms: 5-(1,3-diphenyl-1H-pyrazol-4-yl)-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one
• CAS NO: 221619-50-7
• Molecular Formula: C27H20N4OS
• Molecular Weight: 448.5389
• Mol File: 221619-50-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(1,3-diphenyl-1H-pyrazol-4-yl)-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1,3-diphenyl-1H-pyrazol-4-yl)-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(221619-50-7)
• EPA Substance Registry System: 5-(1,3-diphenyl-1H-pyrazol-4-yl)-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3(2H)-one(221619-50-7)

Safety Data

• Hazardous Substances Data: 221619-50-7(Hazardous Substances Data)

Upstream product

• 144118-63-8 1-phenyl-3-(1,3-diphenyl-1H-pyrazole-4-yl)prop-2-en-1-one 
• 79-11-8 chloroacetic acid 
• 221619-46-1 4-(1,3-diphenyl-1H-pyrazol-4-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidine-2-thione 

Relevant articles and documents

Synthesis and biological screening of new 1,3-diphenylpyrazoles with different heterocyclic moieties at position-4

1,3-Diphenyl-1 H-pyrazole-4-carboxaldehyde (1) was reacted with barbituric acid, thiobarbituric acid, some activated nitriles and/or acetophenone to give the condensation products 2a, b, 3a-c and 4, respectively. The reaction of 1 with hydrazine hydrate, semicarbazide or thiosemicarbazide afforded the corresponding azomethines 5a-c. The compounds 3a, b, 4 and 5a, c were subjected for different sequence reactions to produce the title compounds. The antibacterial and antifungal activity of some selected derivatives were evaluated.