221627-52-7Relevant articles and documents
Intramolecular palladium catalyzed alkoxy carbonylation of 6-hydroxy-1- octenes. Stereoselective synthesis of substituted tetrahydropyrans
White, James D.,Hong, Jian,Robarge, Lonnie A.
, p. 1463 - 1466 (2007/10/03)
The reaction of hydroxy alkenes 5, 7, and 8 with CO and MeOH in the presence of PdCl2 and CuCl2 gave tetrahydropyrans 9, 11, and 12, respectively. Yields were dependent upon the configuration of substituents in the hydroxy alkene; in all cases, the tetrahydropyran was produced with 2,6- cis configuration.