221637-63-4Relevant academic research and scientific papers
F-18 labeling of ether-linked analogs of diacylglycerol
Hatano, Kentaro,Ito, Kengo,Ido, Tatsuo
, p. 245 - 253 (2007/10/03)
Ether-linked analogs of fluorine-18 labeled diacylglycerol were synthesized in order to improve their bioavailability in vivo. Compounds were designed to have long chain (having sixteen carbons) alkyl substituent on 1-O-position and short alkyl or acyl group (eight carbons) on 2-O-position of glycerol. Introduction of 18F into each chain resulted in four labeled tracers. Precursors having tosyloxy or bromo moiety as leaving group were obtained step wise alkylations and/or acylations of 3-O-benzylglycerol. Nucleophilic radiofluorination of the precursors thus obtained gave labeled intermediates in up to 40% radiochemical yield. Ether-linked diacylglycerol analogs were afforded through their deprotection with H2 and Pd/C. Catalytic transfer hydrogenation was also attempted, however, insufficient result was achieved in spite of its usefulness as labeling procedure.
