221656-35-5Relevant academic research and scientific papers
Convenient preparation of some N-substituted 1,2,3,4-tetrahydroisoquinolines lacking electron-donating substituents
Locher
, p. 2895 - 2911 (2001)
N,N-Bis(benzotriazol-1-ylmethyl)-β-phenylethylamines 3 are cyclised intramolecularly in conc. H2SO4 to the corresponding N-benzotriazol-1-ylmethyl-1,2,3,4-tetrahydroisoquinolines 4. The remaining benzotriazolyl-moiety can be replaced by nucleophiles, leading to N-substituted 1,2,3,4-tetrahydroisoquinolines 5-8.
Synthesis of some N-methyl-1,2,3,4-tetrahydroisoquinolines by Friedel-Crafts cyclisation using benzotriazole auxiliary
Locher, Cornelia,Peerzada, Naseem
, p. 179 - 184 (2007/10/03)
1-Hydroxymethylbenzotriazole reacts with phenylethylamines to give the respective N,N-bis(benzotriazol-1-ylmethyl)phenylethylamines, which are then subject to an intramolecular Friedel-Crafts cyclisation at room temperature to yield N-benzotriazol-1-ylmet
