221697-42-3Relevant academic research and scientific papers
Synthesis of artificial glycoconjugate polymers carrying 6-O-phosphocholine α-D-glucopyranoside, biologically active segment of main cell membrane glycolipids of Mycoplasma fermentans
Nishida, Yoshihiro,Takamori, Yusuke,Matsuda, Kazuhiro,Ohrui, Hiroshi,Yamada, Takeshi,Kobayashi, Kazukiyo
, p. 985 - 997 (2007/10/03)
As carbohydrate probes to investigate the biological activity of novel phosphocholine-containing glycoglycerolipids of M. fermentans, artificial glycoconjugate polymers carrying 6-O-phosphocholine α-D-glucopyranoside were synthesized. The synthesis involved α-selective 1-O-p-nitrophenylation (pNP) of 1,6-di-O-acetyl-2,3,4-tri-O-benzyl-D-glucopyranose in the presence of a Lewis acid followed by the introduction of a phosphocholine group at position O-6 by an amidite method. The pNP group was converted into a p-N-methacrylamidophenyl group for subsequent radical polymerization.
