221697-97-8Relevant academic research and scientific papers
Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors
Kitano, Yasunori,Suzuki, Tsuyoshi,Kawahara, Eiji,Yamazaki, Takahisa
, p. 5863 - 5867 (2008/04/03)
The present study identified several 4-alkynyl and 4-alkenylquinazolines that serve as novel and potent EGFR tyrosine kinase inhibitors. The IC50 values of these compounds are in the nanomolar range. In addition, the 4-(4-phenylbut-1-yn/en-yl)q
