2217-41-6

Basic information

• Product Name: 5,6,7,8-Tetrahydro-1-naphthylamine
• Synonyms: 1,2,3,4-Tetrahydro-5-naphthylamine;1-Naphthylamine, 5,6,7,8-tetrahydro-;4-Amino-6-oxo-thioxo-1,2,3,6-tetrahydropyrimidine;5,6,7,8-tetrahydro-1-naphthylamin;5-Amino-1,2,3,4-tetrahydronaphthalene;5-Tetralylamine;alpha-Tetrahydronaphthylamine;5,6,7,8-TETRAHYDRO-1-NAPHTHALENAMINE
• CAS NO: 2217-41-6
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• EINECS: 218-713-2
• Product Categories: Amines;Building Blocks;C10;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 2217-41-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 38 °C(lit.)
• Boiling Point: 275-277 °C713 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to brown/Liquid
• Density: 1,06 g/cm3
• Vapor Pressure: 0.0032mmHg at 25°C
• Refractive Index: n20/D 1.590(lit.)
• Solubility: miscible with Alcohol
• PKA: 4.56±0.20(Predicted)
• BRN: 387264
• CAS DataBase Reference: 5,6,7,8-Tetrahydro-1-naphthylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydro-1-naphthylamine(2217-41-6)
• EPA Substance Registry System: 5,6,7,8-Tetrahydro-1-naphthylamine(2217-41-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: QM4780000
• F: 9
• Hazardous Substances Data: 2217-41-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow to brown liquid

Uses

5,6,7,8-Tetrahydro-1-naphthylamine is used as a reagent in the synthesis of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. 5,6,7,8-Tetrahydro-1-naphthylamine is also used as a reagent in the synthesis of benzopyrans and related compounds as inhibitors of the hypoxia inducible factor pathway.

InChI:InChI=1/C10H13N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7H,1-2,4,6,11H2

Upstream product

• 86-57-7 1-Nitronaphthalene 
• 29809-14-1 5-nitro-1,2,3,4-tetrahydronaphthalene 
• 64-17-5 ethanol 
• 134-32-7 1-amino-naphthalene 
• 602-38-0 1,8-dinitronaphthalene 
• 110-82-7 cyclohexane 
• 479-27-6 naphthalene-1,8-diamine 
• 119-64-2 tetralin 
• 90-15-3 α-naphthol 
• 605-71-0 1,5-dinitronaphthalene 
• 67-56-1 methanol 
• 71-41-0 pentan-1-ol 
• 75-04-7 ethylamine 
• 78422-63-6 4-amino-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid 

Downstream Products

• 13159-91-6 N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4,5-trimethoxybenzylamine 
• 358336-08-0 N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4,5-trimethoxybenzamide 
• 331270-20-3 N-[1-(5,6,7,8-tetrahydronaphthyl)]-3,4-dimethoxybenzamide 
• 22302-73-4 1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin 
• 1279015-46-1 4-[5,6,7,8-tetrahydronaphthalen-1-yl]phenol 

Relevant articles and documents

-

-

Ether compound and pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome

The invention relates to an ether compound and a pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome. Specifically, the invention provides a compound as shown in a formula (I), an isomer, a raceme, a prodrug, a solvate, a deuterated substance or a pharmaceutically acceptable salt thereof, and Ar1, Ar2, X, Y and R are defined in the specification.

Cobalt-Nanoparticles Catalyzed Efficient and Selective Hydrogenation of Aromatic Hydrocarbons

The development of inexpensive and practical catalysts for arene hydrogenations is key for future valorizations of this general feedstock. Here, we report the development of cobalt nanoparticles supported on silica as selective and general catalysts for such reactions. The specific nanoparticles were prepared by assembling cobalt-pyromellitic acid-piperazine coordination polymer on commercial silica and subsequent pyrolysis. Applying the optimal nanocatalyst, industrial bulk, substituted, and functionalized arenes as well as polycyclic aromatic hydrocarbons are selectively hydrogenated to obtain cyclohexane-based compounds under industrially viable and scalable conditions. The applicability of this hydrogenation methodology is presented for the storage of H2 in liquid organic hydrogen carriers.

Method for preparing 5,6,7,8-tetrahydro-1-naphthylamine from 1,8-dinitronaphthalene as raw materials

The invention discloses a method for preparing 5,6,7,8-tetrahydro-1-naphthylamine from 1,8-dinitronaphthalene as raw materials. The method comprises the following steps of using 1,8-dinitronaphthaleneas raw materials; using raney nickel as a catalyst; using hydrogen gas as a reducing agent; performing reaction for 4 to 12 hours in an organic solvent under the conditions of the hydrogen gas pressure being 1.5 to 2.5MPa and the temperature being 120 to 180 DEG C; performing filtering and concentration on reaction liquid to obtain 5,6,7,8-tetrahydro-1-naphthylamine. The synthesis method providedby the invention has the advantages that the operation is simple, convenient and safe; the catalytic hydrogenation is a green synthesis method; the product yield is high; three wastes are less.