2217-58-5Relevant academic research and scientific papers
Overcoming regioselectivity issues inherent in bis-Troeger's base preparation
Havlik, Martin,Kral, Vladimir,Dolensky, Bohumil
, p. 4867 - 4870 (2006)
(Figure Presented) Bis-Troeger's base derivatives are a new family of molecular tweezers. A major drawback to their study is a lack of commercially available precursors, ortho-nitrocarboxylic acids. A reverse synthetic strategy starting from known dinitrodicarboxylic acids, which circumvents this problem, is presented. Via this methodology regioisomeric bis-TB derivatives can be prepared selectively, using only common aromatic amines that are typically commercially available.
