22179-78-8

Basic information

• Product Name: 4-FLUOROBENZAMIDOXIME
• Synonyms: BUTTPARK 52\12-13;4-FLUORO-N-HYDROXY-BENZAMIDINE;4-FLUORO-BENZAMIDE OXIME;4-FLUOROBENZAMIDOXIME;Bolddenone;4-fluoro-N-[(1E)-(hydroxyiMino)Methyl]benzaMide;N-Hydroxy-4-fluorobenzamidine;(E)-4-fluoro-N'-hydroxybenzimidamide
• CAS NO: 22179-78-8
• Molecular Formula: C₇H₇FN₂O
• Molecular Weight: 154.14
• Product Categories: pharmacetical
• Mol File: 22179-78-8.mol
• Article Data: 74

Chemical Properties

• Melting Point: 92-95 °C(lit.)
• Boiling Point: 299.8 °C at 760 mmHg
• Flash Point: 135.1 °C
• Appearance: White/Solid
• Density: 1.3 g/cm³
• PKA: 6.80±0.69(Predicted)
• CAS DataBase Reference: 4-FLUOROBENZAMIDOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZAMIDOXIME(22179-78-8)
• EPA Substance Registry System: 4-FLUOROBENZAMIDOXIME(22179-78-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 22179-78-8(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

4-Fluorobenzamidoxime is used as building block for pharmaceutical, agrochemical, advanced materials etc.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 459-23-4 4-fluorobenzaldoxime 
• 459-57-4 4-fluorobenzaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 184778-36-7 4-fluorobenzamidine acetate 
• 478489-59-7 5-(3-Bromo-furan-2-yl)-3-(4-fluoro-phenyl)-[1,2,4]-oxadiazole 
• 185557-63-5 3-(4-Fluorophenyl)-1,2,4-oxadiazol-5(4H)-one 
• 1220511-99-8 N-cyclohexyl-3-(4-fluorophenyl)-1,2,4-oxadiazol-5-amine 
• 1220512-00-4 3-(4-fluorophenyl)-N-isopropyl-1,2,4-oxadiazol-5-amine 

Relevant articles and documents

Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses

This article describes the synthesis and antiviral activity evaluation of new substituted 1,2,4-oxadiazoles containing a bicyclic substituent at position 5 of the heterocycle and O-acylated amidoximes as precursors for their synthesis. New compounds were

Nitrogen-containing ring derivative inhibitor as well as preparation method and application thereof

The invention relates to a nitrogen-containing ring derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and uses of the compound as a P2X3 inhibitor in treatment of P2X3 receptor dysfunction diseases, especially in treatment of neurogenic diseases.

Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds

Starting from the structure of previously reported 3-Br-isoxazoline-based covalent inhibitors of P. falciparum glyceraldehyde 3-phosphate dehydrogenase, and with the intent to improve their metabolic stability and antimalarial activity, we designed and synthesized a series of simplified analogues that are characterized by the insertion of the oxadiazole ring as a bioisosteric replacement for the metabolically labile ester/amide function. We then further replaced the oxadiazole ring with a series of five-membered heterocycles and finally combined the most promising structural features. All the new derivatives were tested in vitro for antimalarial as well as antileishmanial activity. We identified two very promising new lead compounds, endowed with submicromolar antileishmanial activity and nanomolar antiplasmodial activity, respectively, and a very high selectivity index with respect to mammalian cells.