22186-59-0

Usage

Chemical family

Pyrrole

Physical state

Colorless liquid

Odor

Faint

Solubility

Soluble in water, alcohol, and ether

Primary use

Chemical research and synthesis

Potential applications

Pharmaceutical and agrochemical industries (building block for new drugs and bioactive compounds), organic light-emitting diodes (OLEDs), and as a precursor for making polymers and materials with specific electronic and optical properties.

Upstream product

• 708259-63-6 3-(2-hydroxyethyl)-1-(p-toluenesulfonyl)pyrrole 
• 420787-49-1 2-[1-(triisopropylsilanyl)-1H-pyrrol-3-yl]ethanol 

Downstream Products

• 420787-51-5 [3-(2-hydroxy-ethyl)-1-methyl-1H-pyrrol-2-yl]-phenyl-methanone 
• 420787-65-1 [3-(2-iodo-ethyl)-1-methyl-1H-pyrrol-2-yl]-phenyl-methanone 
• 420787-52-6 2-[2-(2-benzoyl-1-methyl-1H-pyrrol-3-yl)-ethyl]-malonic acid diethyl ester 
• 420787-54-8 1-benzoyl-2-methyl-5,6-dihydro-2H-cyclopenta[c]pyrrole-4,4-dicarboxylic acid diethyl ester 
• 420787-53-7 2-[2-(2-benzoyl-4-iodo-1-methyl-1H-pyrrol-3-yl)-ethyl]-malonic acid diethyl ester 
• 708259-64-7 1-[N-(p-monomethoxytrityl)]-3-(hydroxyethyl)pyrrole 
• 420787-50-4 2-(1-methyl-1H-pyrrol-3-yl)-ethanol 

Relevant academic research and scientific papers

Pyrroles substituted by oligonucleotides

The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using

Synthesis and biological evaluation of Ketorolac analogs

Ketorolac analogs were synthesized and biologically evaluated. For the preparation of the N-methylpyrrole Ro114-1907, and the furan Ro113-8905, a hydroxyethyl-assisted regioselective benzoylation gave intermediates (4) and (12), and subsequently a key copper-mediated ring closure gave entry to the required bicyclic compounds (7) and (15). Ro113-8905 and the thiophene Ro101-8244 significantly inhibited both the writhing response and edema formation in rat, but were less potent than Ketorolac.