22198-72-7

Basic information

• Product Name: 4-AMINOANTIPYRINE HYDROCHLORIDE
• Synonyms: AMPYRONE HYDROCHLORIDE;4-AMINOPHENAZONE HYDROCHLORIDE;4-AMINOANTIPYRINE HCL;4-AMINOANTIPYRINE HYDROCHLORIDE;4-AMINO-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE HYDROCHLORIDE;1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE HYDROCHLORIDE;4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-onmonohydrochloride;4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one monohydrochloride
• CAS NO: 22198-72-7
• Molecular Formula: C₁₁H₁₃N₃O*ClH
• Molecular Weight: 239.7
• EINECS: 244-832-4
• Mol File: 22198-72-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 220-225 °C
• Boiling Point: 309 °C at 760 mmHg
• Flash Point: 140.7 °C
• Appearance: faint yellow to orange crystalline powder
• Vapor Pressure: 0.000659mmHg at 25°C
• Water Solubility: almost transparency
• CAS DataBase Reference: 4-AMINOANTIPYRINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOANTIPYRINE HYDROCHLORIDE(22198-72-7)
• EPA Substance Registry System: 4-AMINOANTIPYRINE HYDROCHLORIDE(22198-72-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 22198-72-7(Hazardous Substances Data)

Usage

Chemical Properties

faint yellow to orange crystalline powder

InChI:InChI=1/C11H13N3O.ClH/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9;/h3-7H,12H2,1-2H3;1H

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 

Downstream Products

• 83-15-8 4-acetylaminoantipyrine 
• 519-98-2 4-methylaminoantipyrine 

Relevant articles and documents

Synthesis, crystal structure, solvatochromic properties and DNA cleaving activity of azo derivative of naphthalen-2-ol

Crystals of naphthol azo compound of 4-aminoantipyrine, C21H18N4O2 have been grown by slow evaporation method from DMF at room temperature. The grown crystals were characterized by FT-IR, UV-Vis, 13C and 1H NMR spectra. The molecular structure was analyzed by single crystal X-ray diffraction data. The compound 4-[(E)-(3-hydroxy naphthalene-2-yl)diazenyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one crystallizes in the monoclinic P21/c space group with cell dimensions a = 18.7902 (12) ? b = 6.4128 (5) ? c = 14.7923 (11) ? and β = 91.229 (2)°. The solvatochromism of dye was evaluated with respect to the wavelength of absorption maxima in nine solvents. Due to the presence of intramolecular hydrogen bonding, hydrazone form predominates in most of the polar protic and polar aprotic solvents. The pH effects on the visible absorption spectra of dye was also reported. The fitting of spectroscopic values to solvent parameters and correlate with the Kamlet-Abboud-Taft equation is also highlighted. The title compound exhibits the single stranded DNA cleaving activity with pUC18 DNA in tris-base buffer (pH 8).