22201-45-2

Basic information

• Product Name: 4-TERT-BUTYLBENZOIC ANHYDRIDE
• Synonyms: 4-TERT-BUTYLBENZOIC ANHYDRIDE
• CAS NO: 22201-45-2
• Molecular Formula: C₂₂H₂₆O₃
• Molecular Weight: 0
• Mol File: 22201-45-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 75-81℃
• Boiling Point: 455.326°C at 760 mmHg
• Flash Point: 209.023°C
• Appearance: /
• Density: 1.057g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 4-TERT-BUTYLBENZOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYLBENZOIC ANHYDRIDE(22201-45-2)
• EPA Substance Registry System: 4-TERT-BUTYLBENZOIC ANHYDRIDE(22201-45-2)

Safety Data

• Hazardous Substances Data: 22201-45-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H26O3/c1-21(2,3)17-11-7-15(8-12-17)19(23)25-20(24)16-9-13-18(14-10-16)22(4,5)6/h7-14H,1-6H3

Upstream product

• 615-36-1 2-bromoaniline 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 201230-82-2 carbon monoxide 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 108-24-7 acetic anhydride 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Downstream Products

• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 1380434-18-3 (4-(tert-butyl)phenyl)(1-tosylpiperidin-4-yl)methanone 
• 28047-27-0 (4-(tert-butyl)phenyl)(cyclohexyl)methanone 
• 1017160-42-7 (4-(tert-butyl)phenyl)(cyclopentyl)methanone 
• 1380434-51-4 1-(4-tert-butylphenyl)-2-(trimethylsilyl)ethanone 
• 1384969-52-1 2-(4-(4-(tert-butyl)phenyl)-3-methyl-4-oxobutyl)isoindoline-1,3-dione 
• 914220-77-2 1-(4-(tert-butyl)phenyl)pentan-1-one 
• 1384969-49-6 piperidine-1,4-diylbis((4-(tert-butyl)phenyl)methanone) 
• 1384969-44-1 4-(4-(tert-butyl)phenyl)-3-methyl-4-oxobutyl 2-methoxybenzoate 
• 1380434-49-0 4-(4-(tert-butyl)phenyl)-3-methyl-4-oxobutyl 4-cyanobenzoate 
• 1384969-46-3 4-(4-(tert-butyl)phenyl)-4-oxobutyl 4-methoxybenzoate 
• 1380434-50-3 1-(4-tert-butylphenyl)-3,3-dimethoxypropan-1-one 
• 60561-82-2 1-(4-(tert-butyl)phenyl)-2-methylpropan-1-one 

Relevant articles and documents

Anhydrides from aldehydes or alcohols via oxidative cross-coupling

A novel type of metal-free oxidative cross-coupling for the synthesis of symmetrical and mixed anhydrides from aldehydes or benzylic alcohols has been developed. The aldehydes or alcohols were converted in situ into their corresponding acyl chlorides, which were then reacted with an array of carboxylic acids. The methodology has a general applicability, and was successfully employed to prepare either aromatic or aliphatic symmetrical anhydrides and mixed anhydrides, which are very unstable compounds.

Oxidative self-coupling of aldehydes in the presence of CuCl2/TBHP system: Direct access to symmetrical anhydrides

A simple synthesis of symmetrical anhydrides has been developed. Using tert-butylhydroperoxide (TBHP) as the oxidant and copper(II) chloride as the catalyst in acetonitrile, various aromatic and heteroaromatic aldehydes were reacted to provide symmetrical anhydrides in modest to good yields.

Synthesis of symmetric anhydrides using visible light-mediated photoredox catalysis

A new approach to anhydride formation is reported via activation of C-O bonds by the Vilsmeier-Haack reagent formed by Ru(bpy)3Cl2 and CBr4 in DMF. Various aryl and alkyl carboxylic acids are converted to the corresponding anhydrides in excellent yields.