222025-82-3

Upstream product

• 79-24-3 Nitroethane 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 

Downstream Products

• 1584-77-6 1,1-bis-(4-fluoro-phenyl)-2-nitro-propane 
• 1555-08-4 1-<4-Fluor-phenyl>-1-<4-iod-phenyl>-2-nitro-propan 
• 1479-86-3 2-Nitro-1-(4-fluor-phenyl)-1-(4-ethyl-phenyl)-propan 
• 2648-09-1 2-Nitro-1-<4-fluor-phenyl>-1-<2.5-dichlor-4-hydroxy-phenyl>-propan 
• 1434076-45-5 (1R,2S)-1-(4-fluorophenyl)-N¹,N²-bis((S)-1-phenylethyl)-propane-1,2-diamine 
• 222026-62-2 1-benzyl-3-(4-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-60-0 1-allyl-3-(4-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-58-6 3-(4-fluoro-phenyl)-1,4-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-14-4 3-(4-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 134538-46-8 1-(4-fluorophenyl)-2-nitropropene 
• 1649-59-8 2-Nitro-1-<4-fluor-phenyl>-1-<4-aethoxy-phenyl>-propan 
• 1584-34-5 2-Nitro-1-<4-fluor-phenyl>-1-p-tolyl-propan 
• 1428-19-9 2-Nitro-1-<4-fluor-phenyl>-1-<2.5-dichlor-4-metylmercapto-phenyl>-propan 
• 2729-16-0 2-Nitro-1-<4-fluor-phenyl>-1-<4-brom-phenyl>-propan 

Relevant academic research and scientific papers

Dynamic kinetic asymmetric ring-opening/reductive amination sequence of racemic nitroepoxides with chiral amines: Enantioselective synthesis of chiral vicinal diamines

We report a highly diastereoselective synthesis of vicinal diamines by the treatment of nitroepoxides with primary amines and then a reducing agent. When using a chiral primary amine, racemic nitroepoxides are transformed into chiral diamines as a single enantiomers (>95:5 er) through a dynamic kinetic asymmetric transformation (DYKAT). The overall process is a one-pot procedure combining the exposure of nitroepoxides to chiral amines to afford diastereomeric mixtures of aminoimines and subsequent stereoselective imine reduction.

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

Polymer-supported reagents and other solid sequestering agents may be used to generate an array of 1,2,3,4-tetra-substituted pyrrole derivatives without any chromatographic purification step.