222047-22-5Relevant academic research and scientific papers
Methylenation and oxidation of chiral non-racemic 2-piperidones: Reactivity of a new 3-oxolactam
Forns, Pilar,Fernández, M. Montserrat,Diez, Anna,Rubiralta, Mario,Cherrier, Marie Pierre,Bonin, Martine,Quirion, Jean-Charles
, p. 258 - 263 (1999)
The preparation of (R)-N-(2-hydroxy-1-phenylethyl)-3- methylenepiperidin-2-one (2) and (R)-N-(2-hydroxy-1-phenylethyl)piperidine- 2,3-dione (3) from the (R)-phenylglycinol-derived lactam 1 is described. We have also studied the reactivity of 3-oxolactam 3, and a series of functionalized derivatives has been prepared.
