222167-67-1

Upstream product

• 1120-87-2 4-bromopyridin 
• 536-74-3 phenylacetylene 
• 154105-64-3 4-bromonicotinaldehyde 

Downstream Products

• 222168-90-3 4-Phenylethynyl-pyridine-3-carbaldehyde oxime 
• 90230-26-5 3-phenyl-[2,7]naphthyridine 

Relevant academic research and scientific papers

Radical Cascade Cyclization: Reaction of 1,6-Enynes with Aryl Radicals by Electron Catalysis

The radical cascade cyclization of various 1,6-enynes with aryl radicals by electron catalysis under metal-free reaction conditions was explored. Readily available anilines were used as radical precursors, and the reactions proceeded in the absence of any transition metal. These cascades comprise three C–C bond formations, which provide polycyclic structures with extended π-systems. The photophysical properties of some of these novel compounds were investigated, and a plausible reaction mechanism is proposed.

General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.