2222-38-0

Upstream product

• 1165-94-2 8-iodo-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 77-78-1 dimethyl sulfate 
• 13738-92-6 (-)-5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''-biflavone 
• 74-88-4 methyl iodide 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 1734-84-5 (E)-1-(2-hydroxy-3-iodo-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 35134-71-5 (aS)-(+)-2,2'-dihydroxy-3,3'-diacetyl-4,4',6,6'-tetramethoxybiphenyl 

Downstream Products

• 13738-92-6 cupressuflavone 4',4',7,7-tetramethyl ether 

Relevant academic research and scientific papers

Synthesis, resolution, and absolute configuration of optically pure 5,5''-dihydroxy-4',4''',7,7''-tetramethoxy-8,8''-biflavone and its derivatives

Optically pure 5,5-dihydroxy-4,4''',7,7''-tetramethoxy-8,8''-biflavone (1) and its dimethyl derivative 5 were synthesized for the first time. Resolution of the racemic (±)-1, prepared by a modified literature procedure, was performed via the formation and recrystallization of its (+)- and (-)-camphorsulfonate 6. Hydrolysis of the (+)- or (-)-camphorsulfonate 6 afforded optically pure (+) or (-)-1, which was then methylated to give (+)- or (-)-5. The absolute configurations of (+)-1 and (-)-1, assigned as (aR) and (aS), respectively, were confirmed in an unambiguous manner by X-ray single crystal analysis and from their CD spectra.

Oxidative Coupling of Phloroacetophenone Dimethyl Ether, Resacetophenone and Resacetophenone Monomethyl Ether Using Silica-Bound FeCl3

Oxidative C-C coupling of phloroacetophenone dimethyl ether, resacetophenone monomethyl ether and resacetophenone with silica-bound ferric chloride yields dimers.While phloroacetophenone dimethylether affords only one dimer, all three possible dimers are obtained from the other two starting compounds.These have been converted into the corresponding biflavones by standard methods.