2222-58-4 Usage
Uses
Used in Pharmaceutical Industry:
Urea, N-cyclohexyl-N'-(cyclohexylmethyl)is used as a pharmaceutical intermediate for the synthesis of various organic compounds. Its role in this industry is crucial for the development of new drugs and pharmaceutical products.
Used in Agrochemical Production:
This urea derivative is used as a reactant in the production of agrochemicals, contributing to the development of effective crop protection products and other agricultural chemicals.
Used in Fine Chemicals Synthesis:
Urea, N-cyclohexyl-N'-(cyclohexylmethyl)is employed as a reactant in the synthesis of fine chemicals, which are essential in various industries such as cosmetics, fragrances, and specialty chemicals.
Used in Medical Research:
Due to its unique chemical structure and properties, Urea, N-cyclohexyl-N'-(cyclohexylmethyl)is being studied for its potential role in the treatment of various medical conditions, indicating its potential use as a therapeutic agent in the future.
Check Digit Verification of cas no
The CAS Registry Mumber 2222-58-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2222-58:
(6*2)+(5*2)+(4*2)+(3*2)+(2*5)+(1*8)=54
54 % 10 = 4
So 2222-58-4 is a valid CAS Registry Number.
2222-58-4Relevant academic research and scientific papers
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases
Morisseau, Christophe,Goodrow, Marvin H.,Newman, John W.,Wheelock, Craig E.,Dowdy, Deanna L.,Hammock, Bruce D.
, p. 1599 - 1608 (2007/10/03)
The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic, and other fatty acid epoxides, endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. 1,3-Disubstituted ureas, carbamates, and amides are new potent and stable inhibitors of sEH. However, the poor solubility of the lead compounds limits their use. Inhibitor structure-activity relationships were investigated to better define the structural requirements for inhibition and to identify points in the molecular topography that could accept polar groups without diminishing inhibition potency. Results indicate that lipophilicity is an important factor controlling inhibitor potency. Polar groups could be incorporated into one of the alkyl groups without loss of activity if they were placed at a sufficient distance from the urea function. The resulting compounds had a 2-fold higher water solubility. These findings will facilitate the rational design and optimization of sEH inhibitors with better physical properties.
