22221-60-9Relevant academic research and scientific papers
The influence of molecular structure and crystallization time on the efficiency of diastereoisomeric salt forming resolutions
Palovics, Emese,Schindler, Jozsef,Faigl, Ferenc,Fogassy, Elemer
, p. 2429 - 2434 (2010)
Reciprocal resolutions between compounds (racemates and enantiomers) with similar structures have been examined. Amongst structurally similar compounds (so called relative structures) several N-acyl amino acids and amino acid esters were investigated. A part of the resolving agent or the racemic compound could be replaced by an achiral compound with a relative structure and an additive could occasionally improve significantly the efficiency of the resolution. Both the kinetic and the thermodynamic controls were observed as governing factors of the reciprocal resolutions.
