22230-97-3

Upstream product

• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 623-91-6 diethyl Fumarate 
• 624-49-7 dimethylfumarate 
• 23055-10-9 1,4-dimethyl but-2-enedioate 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 91139-52-5 trans-4,5-bis(hydroxymethyl)-1,2-dimethylcyclohexene 
• 5680-10-4 4,5-dimethylphthalic acid 
• 6433-42-7 1,2-dimethylcyclohexene-4,5-trans-dicarboxylic acid 
• 1010390-98-3 (1R,2R)-(-)-trans-4,5-dimethyl-1,2-dihydroxy-methylcyclohex-4-ene 
• 1010390-97-2 (1R,2R)-(-)-trans-4,6-dimethylcyclohex-4-ene-1,2-dicarboxylic acid 

Relevant academic research and scientific papers

Syntheses of isomerically pure reference octalins and hydrindanes

We describe herein the development of efficient and stereoselective synthetic routes to a range of cis- and trans-octalin and hydrindane target compounds.

Highly-functionalized arene synthesis based on palladium on carbon-catalyzed aqueous dehydrogenation of cyclohexadienes and cyclohexenes

Transition metal-catalyzed dehydrogenation is a clean oxidation method requiring no additional oxidants. We have accomplished a heterogeneous Pd/C-catalyzed aqueous dehydrogenation of 1,4-cyclohexadienes and cyclohexenes to give the corresponding highly-functionalized arenes. Furthermore, various arenes could be efficiently constructed in a one-pot manner via a Diels-Alder reaction and the following dehydrogenation.

Enantioselective Diels-Alder Reactions of Carboxylic Ester Dienophiles Catalysed by Titanium-Based Chiral Lewis Acid

A new titanium-based chiral Lewis acid 1 has been developed using (1R,2R)-1,2-bis-(2-methoxyphenyl)-ethane-1,2-diol as a chiral vicinal diol ligand. This chiral catalyst was found to exhibit uniformly high enantioselectivity towards carboxylic ester dienophiles in Diels-Alder reactions. The chiral vicinal ligand (1R,2R)-1,2-bis-(2-methoxyphenyl)-ethane-1,2-diol is inexpensive and is easily accessible.

Enantioselective total syntheses of (-)-palau'Amine, (-)-axinellamines, and (-)-massadines

Dimeric pyrrole-imidazole alkaloids represent a rich and topologically unique class of marine natural products. This full account will follow the progression of efforts that culminated in the enantioselective total syntheses of the most structurally ornate members of this family: the axinellamines, the massadines, and palau'Amine. A bio-inspired approach capitalizing on the pseudo-symmetry of the members of this class is recounted, delivering a deschloro derivative of the natural product core. Next, the enantioselective synthesis of the chlorocyclopentane core featuring a scalable, catalytic, enantioselective Diels-Alder reaction of a 1-siloxydiene is outlined in detail. Finally, the successful divergent conversion of this core to each of the aforementioned natural products, and the ensuing methodological developments, are described.

Alicyclic diamine fungicides

Use of a compound having the general formula: STR1 wherein R1, R2, R3 and R4 which may be the same or different represent hydrogen atoms or alkyl groups of 1-6 carbon atoms, or NR1 R2 and/o

The Reaction of Wittig Reagents with Selenium. Formation of Selenoaldehydes

The reaction of Wittig reagents with elemental selenium gave the corresponding selenoaldehydes which further reacted with other Wittig reagents to give the corresponding dimeric olefins in good yields.The selenoaldehydes formed afforded corresponding adducts by the reaction with dienes.These selenoaldehydes obtained by retro Diels-Alder reaction were also found to react with Wittig reagents to give the corresponding olefins in good yields.