22236-04-0 Usage
Description
2-(Difluoromethoxy)aniline, with the molecular formula C7H8F2NO, is an organofluoride and aniline compound characterized by the presence of two fluorine atoms, a methoxy group, and an aniline group. It is primarily utilized in chemical synthesis and research, typically within laboratory settings by experts. Due to limited documentation on its physical and chemical properties, as well as potential hazards and environmental effects, this compound should be handled with caution.
Uses
Used in Chemical Synthesis:
2-(Difluoromethoxy)aniline is used as a chemical intermediate for the synthesis of various organic compounds, particularly those requiring the incorporation of fluorine atoms and the methoxy group. Its unique structure makes it a valuable building block in the development of new pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Research:
In the field of research, 2-(Difluoromethoxy)aniline serves as a key compound for studying the effects of fluorination and methoxylation on the properties and reactivity of organic molecules. It is also used to explore the potential applications of organofluorides and aniline derivatives in various chemical reactions and processes.
Used in Pharmaceutical Industry:
2-(Difluoromethoxy)aniline is used as a precursor in the synthesis of pharmaceutical compounds, where the introduction of fluorine atoms can significantly influence the drug's pharmacokinetics, such as absorption, distribution, metabolism, and excretion. The presence of the methoxy group can also modulate the lipophilicity and solubility of the resulting drug molecules, potentially improving their bioavailability and therapeutic efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Difluoromethoxy)aniline is employed as a starting material for the development of novel pesticides and herbicides. The incorporation of fluorine atoms can enhance the stability, selectivity, and activity of these agrochemicals, leading to more effective and environmentally friendly products.
Used in Specialty Chemicals:
2-(Difluoromethoxy)aniline is utilized in the production of specialty chemicals, such as dyes, pigments, and polymers, where the introduction of fluorine and methoxy groups can impart unique properties, such as improved colorfastness, resistance to UV degradation, and enhanced thermal stability.
Given the limited information on the physical and chemical properties of 2-(Difluoromethoxy)aniline, as well as its potential hazards and environmental effects, it is crucial to handle this compound with care and follow appropriate safety protocols during its use in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 22236-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,3 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 22236-04:
(7*2)+(6*2)+(5*2)+(4*3)+(3*6)+(2*0)+(1*4)=70
70 % 10 = 0
So 22236-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H7F2NO/c8-7(9)11-6-4-2-1-3-5(6)10/h1-4,7H,10H2
22236-04-0Relevant articles and documents
PROCESS FOR PREPARING SUBSTITUTED ANILINES
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, (2022/03/17)
The present invention relates to a process for preparing compounds of the formula (I) starting from compounds of the formula (II) wherein R1, R2, R3 and R3′ are defined in according to the invention.
Synthesis and in vitro antibacterial activity of some 1-(difluoromethoxyphenyl)quinolone-3-carboxylic acids
Xiao,Krishnan,Lin,Delos Santos,Kuck,Babine,Lang Jr.
, p. 585 - 588 (2007/10/02)
We report on the synthesis of N-1-phenylquinolones in which the difluoromethoxy moiety is utilized as a halogen replacement. The antibacterial activity is discussed with reference to N-1-halophenylquinolones.
