222406-18-0

Basic information

• Product Name: 3,3-diethoxy-4-ethyl-1-(4-nitro-benzenesulfonyl)-azetidin-2-one
• Synonyms: 3,3-diethoxy-4-ethyl-1-(4-nitro-benzenesulfonyl)-azetidin-2-one
• CAS NO: 222406-18-0
• Molecular Weight: 372.399
• Mol File: 222406-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,3-diethoxy-4-ethyl-1-(4-nitro-benzenesulfonyl)-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-diethoxy-4-ethyl-1-(4-nitro-benzenesulfonyl)-azetidin-2-one(222406-18-0)
• EPA Substance Registry System: 3,3-diethoxy-4-ethyl-1-(4-nitro-benzenesulfonyl)-azetidin-2-one(222406-18-0)

Safety Data

• Hazardous Substances Data: 222406-18-0(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 222406-13-5 3,3-diethoxy-4-ethyl-azetidin-2-one 

Downstream Products

• 160866-54-6 poststatin 

Relevant articles and documents

Solid and solution phase synthesis of α-keto amides via azetidinone ring-opening: Application to the synthesis of poststatin

3,3-Diethoxy-N-sulfonyl and carbamoyl azetidin-2-ones undergo efficient ring-opening reaction with various amine nucleophiles. Subsequent acid hydrolysis of the ketal moiety generated α-keto amides in excellent overall yields. The naturally occurring serine protease inhibitor poststatin was synthesized using this ring-opening reaction as the key step.