222415-36-3Relevant academic research and scientific papers
Synthesis of enamides via Rh/C-catalyzed direct hydroacylation of ketoximes
Guan, Zheng-Hui,Huang, Kexuan,Yu, Shichao,Zhang, Xumu
supporting information; experimental part, p. 481 - 483 (2009/07/18)
(Chemical Equation Presented) Enamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of ketoximes. Up to 88% isolated yield of enamides were obtained with this method. Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
