22247-87-6 Usage
Uses
Used in Pharmaceutical Industry:
7-(beta-chloroethyl)guanine is used as an inhibitor for hypoxanthine-guanine phosphoribosyltransferase (HGPRT) due to its ability to interfere with the enzyme's function. This inhibition can be beneficial in the development of treatments for certain diseases and conditions where HGPRT plays a crucial role.
Additionally, 7-(beta-chloroethyl)guanine is used as an antiprotozoal agent for its potential to combat protozoan infections. This application is particularly relevant in the treatment of diseases caused by protozoan parasites, such as malaria, leishmaniasis, and trypanosomiasis.
Check Digit Verification of cas no
The CAS Registry Mumber 22247-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,4 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 22247-87:
(7*2)+(6*2)+(5*2)+(4*4)+(3*7)+(2*8)+(1*7)=96
96 % 10 = 6
So 22247-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClN5O/c8-1-2-13-3-10-5-4(13)6(14)12-7(9)11-5/h3H,1-2H2,(H3,9,11,12,14)
22247-87-6Relevant academic research and scientific papers
ALKYLATION OF 6-METHYLTHIO- AND 6-BENZYLOXYGUANINE UNDER PHASE-TRANSFER CONDITIONS
Ramzaeva, N.,Alksnis, E.,Goldberg, Yu.,Lidaks, M.
, p. 3121 - 3128 (2007/10/02)
Phase-transfer-catalyzed alkylation of 6-methylthio- and 6-benzyloxyguanine followed by acid hydrolysis provides a simple procedure for the preparation of various 9- and 7-substituted guanines.
Synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. I. 7-Substituted 6-oxopurines
Piper,Laseter,Montgomery
, p. 357 - 364 (2007/10/02)
Biological evidence indicates that the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) (EC 2.4.2.8) is vital for cell proliferation in malarial parasites but nonessential for mammalian cells. 7-Substituted guanines and hypoxanthines in wh
