222612-99-9Relevant academic research and scientific papers
Antithrombotic diamines
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, (2012/10/23)
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4'' side chain
Bastian, Jolie A.,Chirgadze, Nickolay,Denney, Michael L.,Gifford-Moore, Donetta S.,Sall, Daniel J.,Smith, Gerald F.,Wikel, James H.
, p. 363 - 368 (2007/10/03)
The preparation and biological evaluation of a series of benzo[b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4'' linkers are reported. Compared to the parent compounds 1a/b, the unsaturated derivatives 3a/b exhibited a m
