22263-18-9Relevant articles and documents
Electrochemical benzylic oxidation of C-H bonds
Marko, Jason A.,Durgham, Anthony,Bretz, Stacey Lowery,Liu, Wei
supporting information, p. 937 - 940 (2019/01/23)
Oxidized products have become increasingly valuable as building blocks for a wide variety of different processes and fine chemistry, especially in the benzylic position. We report herein a sustainable protocol for this transformation through C-H functionalization and is performed using electrochemistry as the main power source and tert-butyl hydroperoxide as the radical source for the C-H abstraction. The temperature conditions reported here do not increase above 50 °C and use an aqueous-based medium. A broad substrate scope is explored, along with bioactive molecules, to give comparable and increased product yields when compared to prior reported literature without the use of electrochemistry.
